The process of replicating, or "amplifying" DNA is an integral part of virtually every nucleic acid based test or reaction performed. PCR, the most widely practiced amplification technique, is performed over 1 billion times every year. The methods and devices used to perform amplification can be complicated, large, cumbersome, and slow. They are also not easily miniaturized or integrated into an automated laboratory setting.

Thermal Gradient's technology can enable the ultimate miniaturization and simplification of the amplification process and achieve the fastest rates that the fundamental biochemistry will allow. This means that amplifications that presently takes an hour or longer can be done in a matter of minutes.

Thermal Gradient's flow-through capabilities and simplicity make the technology uniquely suited for miniaturized environments such as Lab-On-A-Chip applications. Additionally, this technology can enable a practical, cost effective and truly random access nucleic acid diagnostic analyzer. Nucleic acid based testing (NAT) can now perform at the same rates and with similar system configurations as those for clinical chemistry and immunochemistry.

Our technology results in microfabricated parts with no moving parts, no in situ heaters, valves, pumps or other components that add complexity and cost.

Please review the following for more information.