Company Profile

Vision and Philosophy

Thermal Gradient was founded with the intention to bring its core technology of very rapid PCR to a suite of products that both better address existing markets and enables new markets that cannot be addressed with existing technologies.

But Thermal Gradient is more that a technology company. Just because we can do something such as very rapid PCR, doesn't mean the company will be successful. Thermal Gradient's business strategy has always been to never get so focused on our technology that we lose sight of the other two ingredients necessary to be successful, namely the needs of the product's intended market and a sound financial model. Thermal Gradient is highly committed to maintaining the proper balance in products that:

Outperform conventional methods and competitive products
Have strong "market pull" because they address unmet needs
Fit comfortably within the financial dynamics of their intended markets

Thermal Gradient was founded by individuals with long and successful track records for developing high technology products in in vitro diagnostics. Our culture is one of strong and spirited collaboration, internally as well as with the company's long term valued partners. We welcome the opportunity to discuss additional opportunities with partners and collaborators that bring additional technologies, resources, and market potentials with Thermal Gradient's reach.

Company Overview

Thermal Gradient is a developer of devices and systems for rapid, easy-to-use molecular diagnostic systems. The company’s proprietary fast thermal cycling and nucleic acid extraction and purification technologies enable extremely fast and easy to use systems ranging from point-of-care to high volume high throughput random access reference systems. These same advantages open up significant licensing and cartridge supply opportunities in bio-defense and other molecular biological applications.

Target Markets:

Point of Care HIV monitoring and screening in low resourse settings
Tuberculosis testing, particularly as an adjunct to the HIV application
Sexually Transmitted Disease testing
Healthcare Acquired Infections such as MRSA
Intra-operative cancer testing
Genetic disorder testing
Bio-defense (biologic threat detection)
Food and water testing
Environmentatl safety testing
Forensics
Genetic research

Key Value Drivers

Thermal Gradient's technology advantage is clearly demonstrated in the HIV detection and screening system presently under development.

Thermal Gradient	Competition
30 minutes sample to answer Useable by minimally trained operators Low cost, field deployable instrument Low cost cartridge Low power / battery powered possible	90 minutes or more Trained laborator technicians required Expensive lab based instrument High manufacturing cost cartridge Line power required

These same advantages can be employed in a wide variety of products and applications.